Screening and Treatment with Microdoses of Bevacizumab for Retinopathy of Prematurity in Hospital Pedro de Bethancourth Antigua Guatemala.

Authors

  • Manuel López Morales
  • Erick Vinicio Saenz Morales
  • Pablo Azurdia
  • Carlos Esquit
  • Paola Salgado
  • Karla Coronado
  • Cristian Rodríguez
  • María Teresa Rubio
  • Karina Hernández
  • Norma Pacaja
  • Sonia Gaytan
  • Miguel Ángel Soto

DOI:

https://doi.org/10.56172/oftalmica.v18i.10

Keywords:

Retinopathy of Prematurity, ROP, Childhood blindness, Pathology

Abstract

Retinopathy of Prematurity (ROP) is an important cause of childhood blindness in fully industrialized countries since 1942. Little by little, as care services in neonatal units in developing countries have improved , this pathology is more frequent. Variations in oxygen concentrations during the first postnatal weeks have been shown to be detrimental and favor the development of ROP. This contributes to both phases of Retinopathy development.

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References

Vinekar A, Dogra M, Azad RV, Gilbert C, Gopal L, Trese M. The changing scenario of retinopathy of prematurity in middle and low income countries: Unique solutions for unique problems. Indian J Ophthalmol 2019;67:717-9 https://doi.org/10.4103/ijo.IJO_496_19

Blencowe H, Lawn JE, Vazquez T, Fielder A, Gilbert C. Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010. Pediatr Res2013;74(Suppl 1):35-49 https://doi.org/10.1038/pr.2013.205

Kong L, Fry M, Al-Samarraie M, Gilbert C, Steinkuller PG. An update on progress and the changing epidemiology of causes of childhood blindness worldwide. J AAPOS2012;16:501-7 https://doi.org/10.1016/j.jaapos.2012.09.004

Guia para la atención integral para la retinopatía del prematuro, Ministerio de Salud y Asistencia Social, Guatemala, octubre 2018.

Zimmermann M, FAng-Sung J, Porras-Jui D, Cotto E, Romero A, Retinopatía del Prematuro en un país en vías de desarrollo. 2009; 83 (6): 323-326.

Sanchez M, Andrews BJ, Karr D, Lansingh V, Withrop KL, The emergence of retinopathy of prematurity in Guatemala. J Pediatr Ophthalmol Strabismus. 2010; 21:47. https://doi.org/10.3928/01913913-20100324-06

Zimmermann M, Rojas M, Galicia I. Caracteristicas de pacientes con retinopatía del prematuro tratado con LASER en el Instituto Guatemalteco De Seguridad Social del 2012 al 2014. Rev Mex Oftalmol. 2017 https://doi.org/10.1016/j.mexoft.2017.02.001

Zimmermann M, Fong-Sung J, Gaete T. Retinopatía del Prematuro en un Hospital Regional de Guatemala. Revista del Colegio de Médicos de Guatemala. 2012; VI (4): 36-40

Burgos V, Del Cid N, Sarti M, Paiz M, Rivas A. Caracterización de la retinopatia del prematuro en el Hospital Nacional de Chimaltenango. Col Med. Guatem 2017; 156 (1): 39-42. https://doi.org/10.36109/rmg.v156i1.53

Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor induced angiogenesis suppresses tumour growth in vivo. Nature. 1993; 362(6423):841-844. [PubMed: 7683111] https://doi.org/10.1038/362841a0

Pierce EA, Avery RL, Foley ED, et al. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci U S A. 1995; 92(3):905-909. [PubMed: 7846076] https://doi.org/10.1073/pnas.92.3.905

Hartnett ME, Penn JS. Mechanisms and management of retinopathy of prematurity. N Engl J Med. 2012; 367(26):2515-2526. [PubMed: 23268666] https://doi.org/10.1056/NEJMra1208129

Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group. Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N Engl J Med. 2011;364(7):603-615. https://doi.org/10.1056/NEJMoa1007374

Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity: Results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 2003;121:1684-94. https://doi.org/10.1001/archopht.121.12.1684

Wu WC, Yeh PT, Chen SN, Yang CM, Lai CC, Kuo HK. Effects and complications of bevacizumab use in patients with retinopathy of pre¬maturity: a multicenter study in Taiwan. Ophthalmology. 2011;118(1):176-183. https://doi.org/10.1016/j.ophtha.2010.04.018

Wu WC, Kuo HK, Yeh PT, Yang CM, Lai CC, Chen SN. An updated study of the use of bevacizumab in the treatment of patients with preth¬reshold retinopathy of prematurity in Taiwan. Am J Ophthalmol. 2013;155(1):150-158. https://doi.org/10.1016/j.ajo.2012.06.010

Harder BC, Schlichtenbrede FC, Von Baltz S, Jendritza W, Jendritza B, Jonas JB. Intracitreal Bevacizumab for Retinopathy of Prematurity: Refractive Error Result. Am J Ophthalmol 2013; 155: 1119-1124. https://doi.org/10.1016/j.ajo.2013.01.014

Azurdia PJ, Squit C. Dosificador para el tratamiento De retinopatia del Prematuro. Tesis de Graduación Universidad Del Valle de Guatemala. 2013

Azurdi PJ, Squit C. Coronado K, Saenz EV. Calculation of the real and efficient bevacizumab dosage for ROP. Scientific poster. Wordl ROP Meeting Cancun 2017.

Wallace DK, Kraker RT, Freedman SF, Crouch ER, Hutchinson AK, Bhatt AR, Rogers DL, Yang MB, Haider KM, VanderVeen DK, Siatkowski RM, Dean TW, Beck RW, Repka MX, Smith LE, Good WV, Hartnett ME, Kong L, Holmes JM; Pediatric Eye Disease Investigator Group (PEDIG). Assessment of Lower Doses of Intravitreous Bevacizumab for Retinopathy of Prematurity: A Phase 1 Dosing Study. JAMA Ophthalmol. 2017 Jun 1;135(6):654-656 https://doi.org/10.1001/jamaophthalmol.2017.1055

Wallace DK. Retinopathy of Prematurity: AntiVEGF treatment for ROP: which drug and what dose? J AAPOS. 2016 Dec;20(6):476-478 https://doi.org/10.1016/j.jaapos.2016.08.013

Published

2020-05-22

How to Cite

López Morales, M., Saenz Morales, E. V., Azurdia, P., Esquit, C., Salgado, P., Coronado, K. ., Rodríguez, C. ., Rubio, M. T. ., Hernández, K. ., Pacaja, N. ., Gaytan, S. ., & Soto, M. Ángel. (2020). Screening and Treatment with Microdoses of Bevacizumab for Retinopathy of Prematurity in Hospital Pedro de Bethancourth Antigua Guatemala. Revista Oftálmica, 18, 11–15. https://doi.org/10.56172/oftalmica.v18i.10

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